MovDisordV3, Main, Exploration, bibRecord, 000F56

The Neurobiology and Neural Circuitry of Cognitive Changes in Parkinson's Disease Revealed by Functional Neuroimaging

Identifieur interne : 000F56 ( Main/Exploration ); précédent : 000F55; suivant : 000F57

The Neurobiology and Neural Circuitry of Cognitive Changes in Parkinson's Disease Revealed by Functional Neuroimaging

Auteurs : Nicola J. Ray [Canada] ; Antonio P. Strafella [Canada]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0423939

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Tomoscintigraphie, Tomographie par émission de positons, Imagerie RMN, Cognition, Fonction exécutive.

English descriptors

KwdEn :
- Animals, Brain (pathology), Brain (physiopathology), Cognition, Cognition Disorders (etiology), Emission tomography, Executive function, Humans, Nerve Net (pathology), Nerve Net (physiopathology), Nervous system diseases, Neurobiology, Neuroimaging, Nuclear magnetic resonance imaging, Parkinson Disease (complications), Parkinson Disease (pathology), Parkinson disease, Positron emission tomography.
MESH :
- complications : Parkinson Disease.
- etiology : Cognition Disorders.
- pathology : Brain, Nerve Net, Parkinson Disease.
- physiopathology : Brain, Nerve Net.
- Animals, Humans, Neurobiology, Neuroimaging.

Abstract

Patients with Parkinson's disease (PD) often develop a spectrum of cognitive symptoms that can evolve into dementia. Dopamine (DA) replacement medications, though improving motor symptoms, can exert both positive and negative effects on cognitive ability, depending on the severity of the disease and the specific skill being tested. By considering the behavioral and clinical aspects of disease- and treatment-mediated changes in cognition alongside the pathophysiology of PD, an understanding of the factors that govern the heterogeneous expression of cognitive impairment in PD is beginning to emerge. Here, we review the neuroimaging studies revealing the neural correlates of cognitive changes after DA loss and DA replacement as well as those that may accompany the conversion from milder stages of cognitive impairment to frank dementia.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452226

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">Patients with Parkinson's disease (PD) often develop a spectrum of cognitive symptoms that can evolve into dementia. Dopamine (DA) replacement medications, though improving motor symptoms, can exert both positive and negative effects on cognitive ability, depending on the severity of the disease and the specific skill being tested. By considering the behavioral and clinical aspects of disease- and treatment-mediated changes in cognition alongside the pathophysiology of PD, an understanding of the factors that govern the heterogeneous expression of cognitive impairment in PD is beginning to emerge. Here, we review the neuroimaging studies revealing the neural correlates of cognitive changes after DA loss and DA replacement as well as those that may accompany the conversion from milder stages of cognitive impairment to frank dementia.</div>
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Movement Disorders (revue)

The Neurobiology and Neural Circuitry of Cognitive Changes in Parkinson's Disease Revealed by Functional Neuroimaging

The Neurobiology and Neural Circuitry of Cognitive Changes in Parkinson's Disease Revealed by Functional Neuroimaging

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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